Louis Thibault, Ph.D.
- New technologies and blood bank process optimization; evaluation of the quality of blood components
- Operational Testing Group (OTG)
Operational Testing Group (OTG)
As blood component supplier, Héma-Québec must use efficient instruments and processes in order to maximize safety and availability of blood products shipped to hospitals. Given the wide variety and the constant evolution of modern technologies, a wise choice of the best technology often requires prior testing. The OTG’s mandate is to provide a framework, within Héma-Québec, for the evaluation of new technologies that can optimize the quality and efficiency of operations related to blood component collection, processing, analysis, and distribution. In parallel to this core activity, the OTG performs research work aimed at optimizing blood component quality, safety, and rational utilization.
Examples of OTG Projects:
- Evaluation of equipment for automation of blood component preparation
- Design qualification of biomedical instruments (blood mixers for use during blood collection, thermal sealers, vital sign measuring apparatuses, hematological analyzers)
- Evaluation of apheresis platelet collection devices
- Optimization of the storage time and temperature of whole blood before component preparation
- Generation and metabolism of kinins in blood components and their possible involvement in transfusion reactions
Blood platelets observed by transmission electron microscopy; magnification: 10,000
- Delage G, Thibault L, Strobl F. (2011). Workflow analysis and performance evaluation of an automated blood testing system. IVD Technology (IVD Technology) 17 (4): 44-49
- Germain M, Thibault L, Jacques A, Tremblay J, Bourgeois R. (2010). Heart valve allograft decontamination with antibiotics: impact of the temperature of incubation on efficacy. Cell Tissue Bank (Cell and Tissue Banking) 11 (2): 197-204.
- Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. (2009). Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion (Transfusion) 49 (11): 2326-2334.
- Thibault L, Beauséjour A, Jacques A, de Grandmont MJ, Lemieux R, Grégoire Y, Ducas É, Boucher G. (2008). Improved leucoreduction of red blood cell units prepared after a 24-h hold with the platelet-rich plasma method using newly developed filters. Vox Sang (Vox Sanguinis) 94 (4): 286-291.
- Néron S, Thibault L, Dussault N, Côté G, Ducas É, Pineault N, Roy A. (2007). Characterization of mononuclear cells remaining in the leukoreduction system chambers of apheresis instruments after routine platelet collection: a new source of viable human blood cells. Transfusion (Transfusion) 47 (06): 1042-1049.
- Moreau ME, Thibault L, Désormeaux A, Chagnon M, Lemieux R, Robillard P, Marceau F, Colman RW, Lepage Y, Rivard GÉ, Adam A. (2007). Generation of kinins during preparation and storage of whole blood-derived platelet concentrates. Transfusion (Transfusion) 47 (03): 410-420.
- Thibault L, Beauséjour A, de Grandmont MJ, Long A, Goldman M, Chevrier MC. (2006). Establishment of an immunoglobulin A-deficient blood donor registry with a simple in-house screening enzyme-linked immunosorbent assay. Transfusion (Transfusion) 46 (12): 2115-2121.
- Thibault L, Beauséjour A, de Grandmont MJ, Lemieux R, Leblanc JF. (2006). Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method. Transfusion (Transfusion) 46 (08): 1292-1299.
- Saldhana J, Shead S, Heath A, Drebot M, et le West Nile Virus Collaborative Study Group. (2005). Collaborative study to evaluate a working reagent for West Nile virus RNA detection by nucleic acid testing. Transfusion (Transfusion) 45 (01): 97-102.