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Maryse St-Louis, Ph. D.

Maryse St-Louis, Ph. D.

Research Scientist, Innovation
Ph.D. Cellular and Molecular Biology, Université Laval, 1996

Adjunct Professor, Department of Biochemistry and Microbiology,
Université Laval

Tel.: 418-780-4362, ext. 3254
Fax: 418-780-2091
Maryse.St-Louis@hema-quebec.qc.ca

Research interests:

  • Genetic and clinical analyses, blood groups, assay development

Current projects:

  • Blood Group Genotyping
  • Nanoparticles Development

Blood Group Genotyping

The International Society of Blood Transfusion acknowledges the existence of 33 blood groups encompassing more than 300 antigens. Fortunately, only a minority of these antigens are clinically relevant. However, the prevalence of these antigens varies between populations, which may lead to the alloimmunization of transfusion-dependent patients. For these patients, the identification of compatible blood involves the screening of a large number of donations. These screening procedures are usually done by agglutination, which requires several specific reagents and a lot of hands-on technical work.

The molecular basis of clinically significant antigens being already known, Dr. St Louis’ team used that knowledge in the development of genotyping tests designed to facilitate the identification of compatible blood for patients, and to characterize clinical samples from complex transfusion cases. In the past few years, this research group has developed several genotyping assays for clinical sample analysis.

Nanoparticles development

New assays are constantly being developed for sample analysis. Research is conducted on optimization and application of a proprietary technology based on nanoparticular antibodies (NanoAb), specifically for imaging and cell labelling (cytometry application). In collaboration with Laval University, a project is under way to develop nanoparticles to genotype blood groups. This innovative technology will facilitate genetic analyses and the identification of compatible donors by its ease of use and short turnaround time.

Expertise:

  • Human Genetics
  • Assay development
  • Technical Assessments

Recent publication

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