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Renée Bazin, Ph.D.

Renée Bazin, Ph.D.

Director, innovation
Ph.D. Biochemistry, Laval University, 1988

Adjunct Professor at the Department of Biochemistry and Microbiology, Faculty of Science and Engineering and at the Faculty of Pharmacy, Laval University

Tel.: 418-780-4362, ext. 3234
Fax: 418-780-2091
Renee.Bazin@hema-quebec.qc.ca

Research interests:

  • Molecular and cellular immunology, stem cells and immunosuppression

Current projects:

  • Mesenchymal Stem Cells and Immunosuppression
  • Hematopoietic Reconstitution Potential of Cord Blood Stem Cells

Mesenchymal Stem Cells and Immunosuppression

The introduction of cellular therapies has led to new approaches in the treatment of many human diseases. In addition to the clinical use of hematopoietic stem cells for immune reconstitution, mesenchymal stem cells (MSC), another type of stem cell, is increasingly attracting attention. Indeed, MSCs have been shown to exert immunosuppressive effects in the treatment of patients suffering from graft-versus-host disease (GvHD). MSCs can be obtained from several sources, including bone marrow, adipose tissue and neonatal tissues such as the umbilical cord and Wharton's jelly. The data available to date indicate that MSCs are safe and immunologically well-tolerated, allowing the use of MSCs prepared from unmatched donors. The aim of our project is to compare the immunosuppressive potential of MSCs from different sources (umbilical cord , bone marrow and adipose tissue) and to select and define optimal parameters for qualifying the therapeutic potential of MSCs in the treatment of GvHD.

Hematopoietic Reconstitution Potential of Cord Blood Stem Cells

Héma-Québec operates the sole public cord blood bank in the Province of Québec. This bank provides the material used for transplantation of hematopoietic stem cells to hospitals. Cord blood banking is done under a regulated environment implemented by the Stem Cell and Reference and Laboratory at Héma-Québec. This procedure includes a step during which the product can be incubated for periods of up to 48 hours at room temperature. The effects of exposure to variable delays and prolonged incubation at room temperature before cryopreservation on the quality and functions of stem cells are currently unknown. In this project, we evaluate the effects of incubation of cord blood at room temperature or at 4°C for variable periods of up to 48 hours on the viability of stem cells. In addition, we measure the ability of these cells to reconstitute the hematopoietic system using the NOD/SCID gamma-null (NSG) mouse model of transplantation. This work will allow us to optimize procedures for cord blood banking in order to preserve the full potential of hematopoietic reconstitution of cord blood stem cells.

Expertise:

  • Mesenchymal stem cells
  • Immune cells
  • Immunomodulation and immunosuppression
  • Animal models
  • Cell culture
  • Immunochemistry
  • Assay development

Recent publications:

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