Trali (Transfusion-Related Acute Lung Injury)
If you have ever been pregnant (including full-term pregnancy, miscarriage, abortion or ectopic pregnancy), you may donate:
- whole blood; and
- plasma by apheresis for use in manufacturing medication.
You cannot give:
- plasma by apheresis for transfusion purposes;
- platelets by apheresis.
QUESTIONS AND ANSWERS
TRALI is an infrequent pulmonary complication occurring within 6 hours of a transfusion. Breathing difficulty is the main symptom and, depending on the severity, it can cause the patient’s death.
This complication occurs in certain patients as a result of the transfusion of blood components containing antibodies, which can cause TRALI. These antibodies are mostly found in plasma and platelets.
Studies have established that women with a history of pregnancy are likely to develop these antibodies, whether the pregnancy was carried to term or was terminated due to miscarriage, abortion, or ectopic pregnancy.
No. The antibodies associated with TRALI pose no threat to donors.
No. Men, like women with no history of pregnancy, have few antibodies associated with TRALI. Accordingly, no particular measure will be applied to male donors.
There is no screening test available at Héma-Québec at the present time.
Can female plasma apheresis donors with a history of pregnancy continue to make donations?
Why can the plasma processed into drug products such as albumin and immunoglobulin be used without risk, unlike plasma given to a patient?
Can female platelet apheresis donors with a history of pregnancy continue to make donations?
Can female HLA-compatible and HPA-typed platelet donors with a history of pregnancy still give platelets by apheresis?
What about whole blood donations?
- Child birth/Breast-feeding/Pregnancy
- Sore throat
- Creutzfeldt-Jakob Disease
- Body piercing/Tattoos
- Tick bite
- Sexual relations
- Trali (Transfusion-Related Acute Lung Injury)
- For more information, please contact our Donor Services at: 1 800 847.2525